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VOLUME 93 (2011) | ISSUE 7 | PAGE 446
Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating
Abstract
We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca2+ SR overload.