Home
For authors
Submission status

Archive
Archive (English)
Current
   Volumes 113-120
   Volumes 93-112
      Volume 112
      Volume 111
      Volume 110
      Volume 109
      Volume 108
      Volume 107
      Volume 106
      Volume 105
      Volume 104
      Volume 103
      Volume 102
      Volume 101
      Volume 100
      Volume 99
      Volume 98
      Volume 97
      Volume 96
      Volume 95
      Volume 94
      Volume 93
Search
VOLUME 108 (2018) | ISSUE 8 | PAGE 580
Cardiac excitation waves under strong hyperkalemia condition
Abstract
Normal blood levels of potassium are critical for maintaining normal heart electrical rhythm. Both low blood potassium levels (hypokalemia) and high blood potassium levels (hyperkalemia) can lead to abnormal heart rhythms. The aim of the work presented was to study the effect of potassium concentration on the excitation wave in the cardiac tissue. Results were obtained, both in the experimental model, which is a monolayer of neonatal rat cardiomyocytes, and using the modified Korhonen computer model, designed for ventricular rat neonatal cardiomyocytes. It was found the existence of non-sodium excitation waves under a strong hyperkalemia (more than 10 mM K + in the extracellular environment) in the cardiomyocyte monolayer, which was also confirmed by inactivation of sodium channels with a specific channel blocker.